京都大学 ウイルス・再生医科学研究所 統合生体プロセス分野
 
 
Lab. of Integrative Biological Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
遺伝子改変マウスをもちいて受精と免疫の融合域を探る

研究成果

原著論文

2012年〜現在

  • Mochizuki AL, Katanaya A, Hayashi E, Hosokawa M, Moribe E, Motegi A, Ishiai M, Takata M, Kondoh G, Watanabe H, Nakatsuji N, Chuma S.
    PARI regulates stalled replication fork processing to maintain genome stability upon replication stress in mice.Mol Cell Biol. 2017 Sep 11.
    https://www.ncbi.nlm.nih.gov/pubmed/28894029
  • Miralles M, Eixarch H, Tejero M, Costa C, Hirota K, Castaño AR, Puig M, Stockinger G, Montalban X, Bosch A, Espejo C, Chillon M.  Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor. Neurotherapeutics. 2017 Jun 7. https://www.ncbi.nlm.nih.gov/pubmed/28593439
  • Watanabe H, Takeda R, Hirota K, Kondoh G. Lipid raft dynamics linked to sperm competency for fertilization in mice. Genes to Cells. 2017 Apr 20
    https://www.ncbi.nlm.nih.gov/pubmed/28425215
  • Yoshimoto Y, Takimoto A, Watanabe H, Hiraki Y, Kondoh G, Shukunami C. Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system. Scientific Reports. 2017 Mar 22.
    https://www.ncbi.nlm.nih.gov/pubmed/28327634
  • Das NR, Miyata H, Hara H, Uchiyama K, Chida J, Yano M, Watanabe H, Kondoh G, Sakaguchi S. Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice. Arc. Virol. 2017 Mar 2.
    https://www.ncbi.nlm.nih.gov/pubmed/28255815
  • Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S.  Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment. Nat Immunol. 2016 Dec 19.
    https://www.ncbi.nlm.nih.gov/pubmed/27992401
  • Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, Takeda K. Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheumatol. 2016 Jun 22.
    http://www.ncbi.nlm.nih.gov/pubmed/27333153
  • Tsuchiya, Y., Y. Minami, Y. Umemura, H. Watanabe, D. Ono, W. Nakamura, T. Takahashi, S. Honma, G. Kondoh, T. Matsuishi, and K. Yagita. Disruption of MeCP2 attenuates circadian rhythm in CRISPR/Cas9-based Rett syndrome model mouse. Genes to Cells, 2015 Dec;20(12):992-1005.
    http://www.ncbi.nlm.nih.gov/pubmed/26456390
  • Sugita, K., S. Hanakawa, T. Honda, G. Kondoh, Y. Miyachi, K. Kabashima, and T. Nomura. Generation of Helios reporter mice and an evaluation of the suppressive capacity of Helios+ regulatory T cells in vitro. Experimental Dermatology, 24-7, 554-556 (2015).
    http://www.ncbi.nlm.nih.gov/pubmed/25846704
  • Watanabe, H., T. Takeo, H. Tojo, K. Sakoh, T. Berger, N. Nakagata, T. W. Mak, and G. Kondoh. Lipocalin2 binds to membrane phosphatidylethanolamine to induce lipid raft movement in a PKA-dependent manner and modulates sperm maturation. Development, 141, 2157-2164 (2014).
    http://www.ncbi.nlm.nih.gov/pubmed/24803661
  • Kim, C-J, Y. Tambe, K-I. Mukaisho, H. Sugihara, T. Isono, H. Sonoda, T. Shimizu, G. Kondoh, and H. Inoue. Female-specific rectal carcinogenesis in cyclin D1b transgenic mice. Carcinogenesis , 35, 227-236 (2014).
    http://www.ncbi.nlm.nih.gov/pubmed/23975835
  • Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali D, Kappler J, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S. Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease. Science. 2014 Oct 17;346(6207):363-8. doi: 10.1126/science.1259077.
    http://www.ncbi.nlm.nih.gov/pubmed/25324392
  • Di Meglio P, Duarte JH, Ahlfors H, Owens ND, Li Y, Villanova F, Tosi I, Hirota K, Nestle FO, Mrowietz U, Gilchrist MJ, Stockinger B. Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions. Immunity. 2014 Jun 19;40(6):989-1001. doi: 10.1016/j.immuni.2014.04.019.
    http://www.ncbi.nlm.nih.gov/pubmed/24909886
  • Umemura Y, J. Yoshida, M. Wada, Y. Tsuchiya, Y. Minami, H. Watanabe, G. Kondoh, J. Takeda, H. Inokawa, K. Horie, and K. Yagita. An in vitro ES cell-based clock recapitulation assay model identifies CK2α as an endogenous clock regulator. PLoS ONE, 8 (6), e67241 (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/23840637
  • Fujihara, Y., Tokuhiro, K., Muro, Y., Kondoh, G., Araki, Y., Ikawa, M., and Okabe, M. Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse sperm. Proc. Natl. Acad. Sci. USA, 110, 8111-8116 (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/23633567
  • Duarte JH, Di Meglio P, Hirota K, Ahlfors H, Stockinger B. Differential Influences of the Aryl Hydrocarbon Receptor on Th17 Mediated Responses in vitro and in vivo. PLoS One. 8:e79819 (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/24244565
  • Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B. Plasticity of TH17 cells in Peyer’s patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol 4, 372-379. (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/23475182
  • Orihashi, K., H. Tojo, K. Okawa, Y. Tashima, T. Morita, and G. Kondoh. Mammalian carboxylesterase (CES) releases GPI-anchored proteins from the cell surface upon lipid raft fluidization. Biol. Chem., 393, 169-176 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22718632
  • Ishimura, A., K-I. Minehata, M. Terashima, G. Kondoh, T. Hara, and T. Suzuki. Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression. Development, 139, 749-759 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22241836
  • Masago Y., A. Hosoya, K. Kawasaki, S. Kawano, A. Nasu, J. Toguchida, K. Fujita, H. Nakamura, G. Kondoh, and K. Nagata. Molucular chaperone Hsp47 is essential for cartilage and endochondral bone formation. J. Cell Sci., 125(5), 1118-1128 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22492985

2011年以前

  • Kadonosono, T., T. Kuchimaru, S. Yamada, Y. Takahashi, A. Murakami, H. Watanabe, T. Tani, M. Inoue, T. Tsukamoto, T. Toyoda, T. Tanaka, K. Hirota, K. Urano, K. Machida, T. Eto, T. Ogura, H. Tsutsumi, M. Ito, M. Hiraoka, G. Kondoh, and S. Kizaka-Kondoh. Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging. PLoS ONE, 6 (11), e26640 (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/22102864
  • Tanaka, T., M. Hosokawa, V-V. Vagin, M. Reuter, E. Hayashi, A-L. Mochizuki, K. Kitamura, H. Yamanaka, G. Kondoh, K. Okawa, S. Kuramochi-Miyagawa, T. Nakano, R. Sachidanandam, G-J. Hannon, R-S. Pillai, N. Nakatsuji, and S. Chuma: Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatid bodies during spermatogenesis. Proc. Natl. Acad. Sci. USA, 108-26, 10579-10584 (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21670278
  • Watanabe, H., and G. Kondoh: Mouse sperm undergo GPI-anchored protein release associated with lipid raft reorganization and acrosome reaction to acquire fertility. J. Cell Sci., 124-15, 2573-2581 (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21750187
  • Wilhelm, C., Hirota, K., Stieglitz, B., Van Snick, J., Tolaini, M., Lahl, K., Sparwasser, T., Helmby, H., and Stockinger, B. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 12, 1071-1077. (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21983833
  • Hirota, K., Duarte, J.H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D.J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U, Garefalaki A, Potocnik AJ, Stockinger B. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12, 255-263. (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21278737
  • Omatsu, Y., T. Sugiyama, H. Kohara, G. Kondoh, N. Fujii, K. Kohno, T. Nagasawa: The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity, 33, 387-399 (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/20850355
  • Tanaka, S., Maeda, S., Hashimoto, M., Fujimori, C., Ito, Y., Teradaira, S., Hirota, K., Yoshitomi, H., Katakai, T., Shimizu, A, Nomura T, Sakaguchi N, Sakaguchi S. Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function. J Immunol 185, 2295-2305. (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/20644168
  • Hashimoto, M., Hirota, K., Yoshitomi, H., Maeda, S., Teradaira, S., Akizuki, S., Prieto-Martin, P., Nomura, T., Sakaguchi, N., Kohl, J, Heyman B, Takahashi M, Fujita T, Mimori T, Sakaguchi S. Complement drives Th17 cell differentiation and triggers autoimmune arthritis. J Exp Med 207, 1135-1143. (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/20457757
  • Shoji, M., T. Tanaka, M. Hosokawa, M. Reuter, A. Stark, Y. Kato, G.Kondoh, K. Okawa, T. Chujo, T. Suzuki, K. Hata, S-L. Martin, T. Noce, S. Kuramochi-Miyagawa, T. Nakano, H. Sasaki, R-S Pillai, N. Nakatsuji, S. Chuma. : The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotrasposon silencing in the mouse male germ line. Dev. Cell, 17, 775-787 (2009).
    http://www.ncbi.nlm.nih.gov/pubmed/20059948
  • Mukai, A., T. Kurisaki, S-B. Sato, T. Kobayashi, G. Kondoh, N. Hashimoto: Dynamic clustering and dispersion of lipid rafts contribute to fusion competence of myogenic cells. Exp. Cell Res., 315, 3052-3063 (2009).
    http://www.ncbi.nlm.nih.gov/pubmed/19615358
  • Watanabe, Y., K. Inoue, A. Okuyama-Yamamoto, N. Nakai, J. Nakatani, K-I Nibu, N. Sato, Y. IIboshi, K. Yusa, G. Kondoh, J. Takeda, T. Terashima, T. Takumi: Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development. J. Comp. Neurol., 515-5, 565-584 (2009).
    http://www.ncbi.nlm.nih.gov/pubmed/19479999
  • Kondoh, G., H. Watanabe, Y. Tashima, Y. Maeda, T. Kinoshita: Testicular Angiotensin-Converting Enzyme with Different Glycan Modification: Characterization on Glycosylphosphatidylinositol-Anchored Protein Releasing and Dipeptidase Activities. J. Biochem., 145-1, 115-121 (2009).
    http://www.ncbi.nlm.nih.gov/pubmed/18984627
  • Veldhoen, M., Hirota, K., Christensen, J., O'Garra, A., and Stockinger, B. Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J Exp Med 206, 43-49. (2009).
    http://www.ncbi.nlm.nih.gov/pubmed/19114668
  • Martin, B., Hirota, K., Cua, D.J., Stockinger, B., and Veldhoen, M. Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 31, 321-330. (2009).
    http://www.ncbi.nlm.nih.gov/pubmed/19682928
  • Wakasa-Morimoto C, Toyosaki-Maeda T, Matsutani T, Yoshida R, Nakamura-Kikuoka S, Maeda-Tanimura M, Yoshitomi H, Hirota K, Hashimoto M, Masaki H, Fujii Y, Sakata T, Tsuruta Y, Suzuki R, Sakaguchi N, Sakaguchi S. Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis. Int. Immunol. 10:1331-42. (2008)
    http://www.ncbi.nlm.nih.gov/pubmed/18711120
  • Veldhoen, M., Hirota, K., Westendorf, A.M., Buer, J., Dumoutier, L., Renauld, J.C., and Stockinger, B. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453, 106-109. (2008).
    http://www.ncbi.nlm.nih.gov/pubmed/18362914
  • Deguchi, E., T. Tani, H. Watanabe, S. Yamada, G. Kondoh: Dipeptidase-inactivated tACE action in vivo: selective inhibition of sperm-zona pellucida binding in the mouse. Biol. Reprod., 77, 794-802 (2007).
    http://www.ncbi.nlm.nih.gov/pubmed/17634445
  • Hirota, K., Yoshitomi, H., Hashimoto, M., Maeda, S., Teradaira, S., Sugimoto, N., Yamaguchi, T., Nomura, T., Ito, H., Nakamura, T, Sakaguchi N, Sakaguchi S. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 204, 2803-2812. (2007).
    http://www.ncbi.nlm.nih.gov/pubmed/18025126
  • Yamaguchi, T., Hirota, K., Nagahama, K., Ohkawa, K., Takahashi, T., Nomura, T., and Sakaguchi, S. Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 27, 145-159. (2007).
    http://www.ncbi.nlm.nih.gov/pubmed/17613255
  • Hirota, K., Hashimoto, M., Yoshitomi, H., Tanaka, S., Nomura, T., Yamaguchi, T., Iwakura, Y., Sakaguchi, N., and Sakaguchi, S. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 204, 41-47. (2007).
    http://www.ncbi.nlm.nih.gov/pubmed/17227914
  • Yae, K., V-W. Keng, M. Koike, K. Yusa, M. Kouno, Y. Uno, G. Kondoh, T. Gotow, Y. Uchiyama, K. Horie, and J. Takeda: Sleeping Beauty Transposon-Based Phenotypic Analysis of Mice: Lack of Arpc3 Results in Defective Trophoblast Outgrowth. Mol. Cell Biol., 26, 6185-6196(2006).
    http://www.ncbi.nlm.nih.gov/pubmed/16880528
  • Rhee, J. M., M. K. Pirity, C. S. Lackan, J. Z. Long, G. Kondoh, J. Takeda, and A-K. Hadjantonakis: In vivo imaging and differential localization of lipid-modified GFP-variant fusions in embryonic stem cells and mice. Genesis, 44, 202-218 (2006).
    http://www.ncbi.nlm.nih.gov/pubmed/16604528
  • Sugimoto, N., Oida, T., Hirota, K., Nakamura, K., Nomura, T., Uchiyama, T., and Sakaguchi, S. Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol 18, 1197-1209. (2006)
    http://www.ncbi.nlm.nih.gov/pubmed/16772372
  • Kondoh, G., H. Tojo, Y. Nakatani, N. Komazawa, C. Murata, K. Yamagata, Y. Maeda, T. Kinoshita, M. Okabe, R. Taguchi and J. Takeda: Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat. Med., 11, 160-166 (2005).
    http://www.ncbi.nlm.nih.gov/pubmed/15665832
  • Yoshitomi, H., Sakaguchi, N., Kobayashi, K., Brown, G.D., Tagami, T., Sakihama, T., Hirota, K., Tanaka, S., Nomura, T., Miki, I, Gordon S, Akira S, Nakamura T, Sakaguchi S. A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med 201, 949-960. (2005).
    http://www.ncbi.nlm.nih.gov/pubmed/15781585
  • Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., Shimizu, J., Nomura, T., Chiba, T., and Sakaguchi, S. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med 202, 885-891. (2005).
    http://www.ncbi.nlm.nih.gov/pubmed/16186187
  • Nishida K, O. Yamaguchi, S. Hirotani, S. Hikoso, Y. Higuchi, T. Watanabe, T. Takeda, S. Osuka, T. Morita, G. Kondoh, Y. Uno, K. Kashiwase, M. Taniike, A. Nakai, Y. Matsumura, J-I. Miyazaki, T. Sudo, K. Hongo, Y. Kusakari, S. Kurihara, K. R. Chien, J. Takeda, M. Hori and K. Otsu : p38α Mitogen-Activated Protein Kinase Plays a Critical Role in Cardiomyocyte Survival but Not in Cardiac Hypertrophic Growth in Response to Pressure Overload. Mol. Cell Biol., 24, 10611-10620 (2004).
  • Kouno, M., G. Kondoh, K. Horie, N. Komazawa, N. Ishii, Y. Takahashi, J. Takeda, and T. Hashimoto: Ahnak/Desmoyokin is dispensable for proliferation, differentiation, and maintenance of integrity in mouse epidermis. J. Invest. Dermatol., 123, 700-707 (2004).
  • Yusa, K., K. Horie, G. Kondoh, M. Kouno, Y. Maeda, T. Kinoshita, and J. Takeda: Genome-wide phenotype analysis in ES cells by regulated disruption of the Bloom’s syndrome gene. Nature, 429, 896-899 (2004).
  • Horie, K., K. Yusa, K. Yae, J. Odajima, S. E. J. Fischer, V. W. Keng, T. Hayakawa, S. Mizuno, G. Kondoh, T. Ijiri, Y. Matsuda, R.H. Plasterk and J. Takeda: Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol. Cell Biol., 23, 9189-9207 (2003).
  • Takagi, S., H. Tojo, S. Tomita, S. Sano, S. Itami, M. Hara, S. Inoue, K. Horie, G. Kondoh, K. Hosokawa, F. J. Gonzalez and Junji Takeda: Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt deficient mice exhibits skin barrier function. J. Clin. Inv., 112, 1372-1382 (2003).
  • Alfieri, J. A., A. D. Martin, J. Takeda, G. Kondoh, D. G. Myles and P. Primakoff: Infertility in female mice with an oocyte-specific knockout of GPI-anchored proteins. J. Cell Sci., 116, 2149-2155 (2003).
  • Umeda J., S. Sano, K. Kogawa, N. Motoyama, K. Yoshikawa, S. Itami,
  • G. Kondoh, T. Watanabe and J. Takeda: In vivo cooperation between Bcl-XL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis. FASEB J., 17, 610-620 (2003).
  • Suzuki Y., H. Miura, A. Tanemura, K. Kobayashi, G. Kondoh, S. Sano, K. Ozawa, S. Inui, A. Nakata, T. Takagi, M. Tohyama, K. Yoshikawa and S. Itami: Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia. FEBS Lett., 521, 67-71 (2002).
  • Gao, X-H., G. Kondoh, M. Tarutani, M. Hara, S. Inoue, T. Nakanishi, M. Okabe, Y. Yamaguchi, K. Yoshikawa, S. Itami, and J. Takeda: Rapid compensation for Glycosylphosphatidylinositol (GPI)-anchor deficient keratinocytes after birth: visualization of GPI-anchored proteins in situ. J. Invest. Dermatol. , 118, 998-1002 (2002).
  • Koike, K., K. Horie, H. Fukuyama, G. Kondoh, S. Nagata, and J. Takeda: Efficient biallelic mutagenesis with Cre/loxP-mediated inter-chromosomal recombination. EMBO reports, 3-5, 433-437 (2002).
  • Horie, K., A. Kuroiwa, M. Ikawa, M. Okabe, G. Kondoh, Y. Matsuda, and J. Takeda: Efficient chromosomal transposition of a Tc1/mariner-like transposon Sleeping Beauty in mice. Proc. Natl. Acad. Sci. USA, 98, 9191-9196 (2001).
  • Kawane, K., H. Fukuyama, G. Kondoh, J. Takeda, Y. Ohsawa, Y. Uchiyama, and S. Nagata: Requirement of DNase II for defenitive erythropoiesis in the mouse fetal liver. Science, 292, 1546-1549 (2001).
  • Takeda, J., S. Sano, M. Tarutani, J. Umeda, and G. Kondoh: Conditional gene targeting and its application in the skin. J. Dermatol. Sci., 23, 147-154 (2000).
  • Kawamoto, S., H. Niwa, F. Tashiro, S. Sano, G. Kondoh, J. Takeda, K. Tabayashi, J-I. Miyazaki: A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination. FEBS Lett., 470, 263-268 (2000).
  • Kondoh, G., X-H. Gao, Y. Nakano, Y. Koike, S. Yamada, M. Okabe, and J. Takeda: Tissue-inherent fate of GPI revealed by GPI-anchored GFP transgenesis. FEBS Lett., 458-3, 299-303 (1999).
  • Nakano, Y., G. Kondoh, T. Kudo, K. Imaizumi, M. Kato, J-I Miyazaki, M. Tohyama, J. Takeda, and M. Takeda: Accumulation of murine amyloid β42 with a gene-dosage dependent manner in PS1 ”knock-in” mice. Euro. J. Neurosci., 11-7, 2577-2581 (1999).
  • Kondoh, G., Y. Yamamoto, K. Yoshida, Y. Suzuki, S. Osuka, Y. Nakano, T. Morita, and J. Takeda : Easy assessment of ES cell clone potency for chimeric development and germ-line competency by an optimized aggregation method. J. Biochem. Biophy. Methods., (現J. of proteomics)39-3, 137-142 (1999).
  • Yamamoto, Y., H. Yoshikawa, S. Nagano, G. Kondoh, S. Sadahiro, T. Gotow, T. Yanagihara, and S. Sakoda: Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in the central nervous system myelin. Euro. J. Neurosci., 11, 847-855 (1999).
  • Li, Q., N. Yoshioka, M. Yutsudo, S. Inafuku, K. Aozasa , S. Aizawa, Y. Kitamura, Y. Nishimune, A. Hakura, and G. Kondoh: HPV-induced carcinogenesis with p53 deficiency in mouse: novel lymphomagenesis in HPV16E6E7 transgenic mice mimicking p53 defect. Virology, 252, 28-33 (1998).
  • Yoshida, K., G. Kondoh, Y. Matsuda, T. Habu, Y. Nishimune, and T. Morita: The mouse RecA-like gene, Dmc1 is required for homologous synapsis of chromosomes during meiosis. Mol. Cell, 1, 707-718 (1998).
  • Matsuki, M., F. Yamashita, A. Ishida-Yamamoto, K. Yamada, C. Kinoshita, S. Fushiki, E. Ueda, Y. Morishima, K. Tabata, H. Yasuno, M. Hashida, H. Iizuka, M. Ikawa, M. Okabe, G. Kondoh, T. Kinoshita, J. Takeda, and K. Yamanishi: Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase). Proc. Natl. Acad. Sci. USA, 95, 1044-1049 (1998)
  • Ishiwatari, H., K. Nakanishi, G. Kondoh, N. Hayasaka, Q. Li, A. Yamashita, H. Inoue, and A. Hakura: Suppression of tumor growth by the 3' untranslated region of mel-18 in 3Y1 cells transformed by the E6 and E7 genes of human papillomavirus type 18. Cancer Lett., 117, 57-65 (1997)
  • Kondoh, G., K. Yomogida, K. Dohmae, M. Nozawa, M. Koga, N. Nonomura, T. Miki, A. Okuyama and Y. Nishimune: Coexpression of multiple Sertoli cell and Leydig cell marker genes in the spontaneous testicular umor of F344 rat: evidence for phenotypical bifurcation of the interstitial cell tumor. Jpn. J. Cancer Res. (現Cancer sci.) 88, 839-845 (1997)
  • Li Q., G. Kondoh, S. Inafuku, Y. Nishimune, and A. Hakura: Abrogation of c-kit/steel factor-dependent tumorigenesis by kinase defective mutants of the c-kit receptor: c-kit kinase defective mutants as a candidate tools for cancer gene therapy. Cancer Res., 56, 4343-4346 (1996)
  • Kondoh, G., Q. Li, J. Pang, and A. Hakura: Transgenic models for papillomavirus-associated multistep carcinogenesis. Intervirology, 38, 181-186 (1995)
  • Kondoh, G., N. Hayasaka, Q. Li, Y. Nishimune, and A. Hakura: An in vivo model for receptor tyrosine kinase autocrine/paracrine activation: auto-stimulated KIT receptor acts as a tumor promoting factor in papillomavirus-induced tumorigenesis. Oncogene, 10, 341-347 (1995)
  • Sasagawa, T., G. Kondoh, M. Inoue, M. Yutsudo, and A.Hakura: Cervical/vaginal dysplasias of the transgenic mice harbouring human papillomavirus type 16 E6-E7 genes. J. Gen. Virol., 75, 3057-3065 (1994)
  • Kondoh, G., Y. Nishimune, Y. Nishizawa, N. Hayasaka, K. Matsumoto, and A. Hakura: Establishment and further characterization of a line of transgenic mice showing testicular tumorigenesis at 100% incidence. J. Urol., 152, 2151-2154 (1994)
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