研究成果

原著論文

2012年~現在

  • Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice.
    Ohara D, Takeuchi Y, Watanabe H, Lee Y, Mukoyama H, Ohteki T, Kondoh G, Hirota K.
    J Exp Med. 2024 Feb 5;221(2):e20230923. doi: 10.1084/jem.20230923. Epub 2024 Jan 5. PMID: 38180443
    https://pubmed.ncbi.nlm.nih.gov/38180443/
  • Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.
    Uehata T, Yamada S, Ori D, Vandenbon A, Giladi A, Jelinski A, Murakawa Y, Watanabe H, Takeuchi K, Toratani K, Mino T, Kiryu H, Standley DM, Tsujimura T, Ikawa T, Kondoh G, Landthaler M, Kawamoto H, Rodewald HR, Amit I, Yamamoto R, Miyazaki M, Takeuchi O.
    Blood. 2023 Nov 3:blood.2023020903. doi: 10.1182/blood.2023020903. Online ahead of print. PMID: 37922454
    https://pubmed.ncbi.nlm.nih.gov/37922454/
  • Identification of Surface Markers and Functional Characterization of Myeloid Derived Suppressor Cell-Like Adherent Cells.
    Co Soriano JC, Tsutsumi S, Ohara D, Hirota K, Kondoh G, Niwa T, Taguchi H, Kadonosono T, Kizaka-Kondoh S.
    Adv Biol (Weinh). 2023 Nov 20:e2300159. doi: 10.1002/adbi.202300159. Online ahead of print. PMID: 37986133
    https://pubmed.ncbi.nlm.nih.gov/37986133/
  • Ebf3+ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells.
    Nakatani T, Sugiyama T, Omatsu Y, Watanabe H, Kondoh G, Nagasawa T.
    Nat Commun. 2023 Oct 25;14(1):6402. doi: 10.1038/s41467-023-42047-2. PMID: 37880234
    https://pubmed.ncbi.nlm.nih.gov/37880234/
  • In vivo optical imaging of tumor stromal cells with hypoxia-inducible factor activity.
    Miyabara H, Hirano R, Watanabe S, Soriano JCC, Watanabe H, Kuchimaru T, Kitada N, Kadonosono T, Maki SA, Kondoh G, Kizaka-Kondoh S. Cancer Sci. 2023 Oct;114(10):3935-3945. doi: 10.1111/cas.15907. Epub 2023 Jul 22. PMID: 37482942
    https://pubmed.ncbi.nlm.nih.gov/37482942/
  • Dimethyl-α-cyclodextrin induces capacitation by removing phospholipids from the plasma membrane of mouse sperm†.
    Nakao S, Ito K, Sakoh K, Takemoto K, Watanabe H, Kondoh G, Irie T, Nakagata N, Takeo T.
    Biol Reprod. 2023 Apr 11;108(4):671-681. doi: 10.1093/biolre/ioad013. PMID: 36723878
    https://pubmed.ncbi.nlm.nih.gov/36723878/
  • Synchronization of the ovulation and copulation timings increased the number of in vivo fertilized oocytes in superovulated female mice.
    Nakao S, Ito K, Sugahara C, Watanabe H, Kondoh G, Nakagata N, Takeo T.
    PLoS One. 2023 Feb 6;18(2):e0281330. doi: 10.1371/journal.pone.0281330. eCollection 2023. PMID: 36745586
    https://pubmed.ncbi.nlm.nih.gov/36745586/
  • Phase separation of an actin nucleator by junctional microtubules regulates epithelial function.
    Tsukita K, Kitamata M, Kashihara H, Yano T, Fujiwara I, Day TF, Katsuno T, Kim J, Takenaga F, Tanaka H, Park S, Miyata M, Watanabe H, Kondoh G, Takahashi R, Tamura A, Tsukita S.
    Sci Adv. 2023 Feb 15;9(7):eadf6358. doi: 10.1126/sciadv.adf6358. Epub 2023 Feb 15. PMID: 36791197
    https://pubmed.ncbi.nlm.nih.gov/36791197/
  • Tissue-resident macrophages are major tumor-associated macrophage resources, contributing to early TNBC development, recurrence, and metastases.
    Hirano R, Okamoto K, Shinke M, Sato M, Watanabe S, Watanabe H, Kondoh G, Kadonosono T, Kizaka-Kondoh S.
    Commun Biol. 2023 Feb 3;6(1):144. doi: 10.1038/s42003-023-04525-7. PMID: 36737474
    https://pubmed.ncbi.nlm.nih.gov/36737474/
  • Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease.
    Tanaka A, Maeda S, Nomura T, Llamas-Covarrubias MA, Tanaka S, Jin L, Lim EL, Morikawa H, Kitagawa Y, Akizuki S, Ito Y, Fujimori C, Hirota K, Murase T, Hashimoto M, Higo J, Zamoyska R, Ueda R, Standley DM, Sakaguchi N, Sakaguchi S.
    J Exp Med. 2023 Feb 6;220(2):e20220386. doi: 10.1084/jem.20220386. Epub 2022 Dec 1. PMID: 36454183
    https://pubmed.ncbi.nlm.nih.gov/36454183/
  • Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model.
    Lee S, Hirota K, Schuette V, Fujita T, Kato H.
    Biochem Biophys Res Commun. 2022 Nov 12;629:171-175. doi: 10.1016/j.bbrc.2022.09.017. Epub 2022 Sep 7. PMID: 36122455
    https://pubmed.ncbi.nlm.nih.gov/36122455/
  • Comparison of biological measurement and physical estimates of space radiation in the International Space Station.
    Yoshida K, Hada M, Kizu A, Kitada K, Eguchi-Kasai K, Kokubo T, Teramura T, Yano S, Suzuki HH, Watanabe H, Kondoh G, Nagamatsu A, Saganti P, Cucinotta FA, Morita T. Heliyon.
    2022 Aug 18;8(8):e10266. doi: 10.1016/j.heliyon.2022.e10266. eCollection 2022 Aug. PMID: 36061033
    https://pubmed.ncbi.nlm.nih.gov/36061033/
  • Shirakashi M, Maruya M, Hirota K, Tsuruyama T, Matsuo T, Watanabe R, Murata K, Tanaka M, Ito H, Yoshifuji H, Ohmura K, Elewaut D, Sakaguchi S, Fagarasan S, Mimori T, Hashimoto M.
    Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity.
    Arthritis Rheumatol. 2022 Apr;74(4):641-653. doi: 10.1002/art.42016. Epub 2022 Feb 25. PMID: 34725966
    https://pubmed.ncbi.nlm.nih.gov/34725966/
  • Omatsu Y, Aiba S, Maeta T, Higaki K, Aoki K, Watanabe H, Kondoh G, Nishimura R, Takeda S, Chung UI, Nagasawa T.
    Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells
    Nat Commun. 2022 May 12;13(1):2654. doi: 10.1038/s41467-022-30266-y.
    https://pubmed.ncbi.nlm.nih.gov/35551452/
  • Umemura Y, Koike N, Tsuchiya Y, Watanabe H, Kondoh G, Kageyama R, Yagita K.
    Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids
    Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2114083119. doi: 10.1073/pnas.2114083119.
    https://pubmed.ncbi.nlm.nih.gov/34930826/
  • Nakagawa T, Jörg DJ, Watanabe H, Mizuno S, Han S, Ikeda T, Omatsu Y, Nishimura K, Fujita M, Takahashi S, Kondoh G, Simons BD, Yoshida S, Nagasawa T.
    A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis.
    Cell Rep. 2021 Oct 19;37(3):109875.
    https://pubmed.ncbi.nlm.nih.gov/34686326/
  • Takeuchi Y, Ohara D, Watanabe H, Sakaguchi N, Sakaguchi S, Kondoh G, Morinobu A, Mimori T, Hirota K.
    Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis.
    Sci Rep. 2021 Sep 21;11(1):18679.
    https://pubmed.ncbi.nlm.nih.gov/34548542/
  • Kawakami R, Kitagawa Y, Chen KY, Arai M, Ohara D, Nakamura Y, Yasuda K, Osaki M, Mikami N, Lareau CA, Watanabe H, Kondoh G, Hirota K, Ohkura N, Sakaguchi S.
    Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells.
    Immunity. 2021 May 11;54(5):947-961.e8.
    https://pubmed.ncbi.nlm.nih.gov/33930308/
  • Nakato M, Shiranaga N, Tomioka M, Watanabe H, Kurisu J, Kengaku M, Komura N, Ando H, Kimura Y, Kioka N, Ueda K.
    ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking.
    J Biol Chem. 2021 Jan-Jun;296:100166.
    https://pubmed.ncbi.nlm.nih.gov/33478937/
  • Ikeno Y, Ohara D, Takeuchi Y, Watanabe H, Kondoh G, Taura K, Uemoto S,Hirota K.
    Foxp3+ regulatory T cells inhibit CCl4-induced liver inflammation and fibrosis by regulating tissue cellular immunity.
    Front Immunol. 11:584048.(2020)
    https://pubmed.ncbi.nlm.nih.gov/33178216/
  • Uchiyama K, Miyata H, Yamaguchi Y, Imamura M, Okazaki M, Pasiana AD, Chida J, Hara H, Atarashi R, Watanabe H, Kondoh G, Sakaguchi S.
    Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91-106.
    Int J Mol Sci. 2020 Oct 1;21(19):7260.
    https://pubmed.ncbi.nlm.nih.gov/33019549/
  • Miyazaki K, Watanabe H, Yoshikawa G, Chen K, Hidaka R, Aitani Y, Osawa K, Takeda R, Ochi Y, Tani-Ichi S, Uehata T, Takeuchi O, Ikuta K, Ogawa S, Kondoh G, Lin YC, Ogata H, Miyazaki M.
    The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells.
    Sci Immunol. 2020 Sep 4;5(51):eabb1455.
    https://pubmed.ncbi.nlm.nih.gov/32887843/
  • Nakao S, Takeo T, Watanabe H, Kondoh G, Nakagata N.
    Successful selection of mouse sperm with high viability and fertility using microfluidics chip cell sorter.
    Sci Rep. 2020 Jun 1;10(1):8862.
    https://pubmed.ncbi.nlm.nih.gov/32483250/
  • Hirotsune S, Kiyonari H, Jin M, Kumamoto K, Yoshida K, Shinohara M, Watanabe H, Wynshaw-Boris A, Matsuzaki F.
    Enhanced homologous recombination by the modulation of targeting vector ends.
    Sci Rep. 2020 Feb 13;10(1):2518.
    https://pubmed.ncbi.nlm.nih.gov/32054870/
  • Das NR, Miyata H, Hara H, Chida J, Uchiyama K, Masujin K, Watanabe H, Kondoh G, Sakaguchi S.
    The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region.
    Mol Neurobiol. 2020 Feb;57(2):1203-1216. doi: 10.1007/s12035-019-01804-5.
    https://pubmed.ncbi.nlm.nih.gov/31707632/
  • Akamatsu M, Mikami N, Ohkura N, Kawakami R, Kitagawa Y, Sugimoto A, Hirota K, Nakamura N, Ujihara S, Kurosaki T, Hamaguchi H, Harada H, Xia G, Morita Y, Aramori I, Narumiya S, Sakaguchi S.
    Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19.
    Sci Immunol. 4. pii: eaaw2707. (2019)
    https://pubmed.ncbi.nlm.nih.gov/31653719/
  • Hojo MA, Masuda K, Hojo H, Nagahata Y, Yasuda K, Ohara D, Takeuchi Y, Hirota K, Suzuki Y, Kawamoto H, Kawaoka S.
    Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection.
    Nat Commun. 10:2603. (2019)
    https://pubmed.ncbi.nlm.nih.gov/31197149/
  • Itoh K, Kondoh G, Miyachi H, Sugai M, Kaneko Y, Kitano S, Watanabe H, Maeda R, Imura A, Liu Y, Ito C, Itohara S, Toshimori K, Fujita J.
    Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo.
    Sci Signal. 2019 Mar 26;12(574).
    https://www.ncbi.nlm.nih.gov/pubmed/30914484
  • Takimoto A, Kokubu C, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y, Shukunami C.
    Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation.
    Sci Rep. 2019 Mar 14;9(1):4605.
    https://www.ncbi.nlm.nih.gov/pubmed/30872687
  • Yasuda K, Kitagawa Y, Kawakami R, Isaka Y, Watanabe H, Kondoh G, Kohwi-Shigematsu T, Sakaguchi S, Hirota K..
    Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation. Nat Commun. 2019 Feb 1;10(1):549.
    https://www.ncbi.nlm.nih.gov/pubmed/30710091
  • Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S.
    Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis. Immunity. 2018 May 22. [Epub ahead of print]
    https://www.ncbi.nlm.nih.gov/pubmed/29802020
  • Seike, M., Y. Omatsu, H. Watanabe, G. Kondoh, T. Nagasawa.
    Stem cell niche-specific EBF3 maintains the bone marrow cavity. Genes Dev., doi: 10.1101/gad.311068.117 (2018).
    https://www.ncbi.nlm.nih.gov/pubmed/29563184
  • Morita, M., T. Sato, M. Nomura, Y. Sakamoto, Y. Inoue, R. Tanaka, S. Ito, K. Kurosawa, K. Yamaguchi, Y. Sugiura, H. Takizaki, Y. Yamashita, R. Katakura, I. Sato, M. Kawai, Y. Okada, H. Watanabe, G. Kondoh, S. Matsumoto, A. Kishimoto, M. Obata, M. Matsumoto, T. Fukuhara, H. Motohashi, M. Suematsu, M. Komatsu, K-I. Nakayama, T. Watanabe, T. Soga, H. Shima, M. Maemondo, N. Tanuma.
    PKM1 confers metabolic advantages and promotes cell-autonomous tumor cell growth. Cancer Cell, 33(3):355-367.e7. doi: 10.1016/j.ccell.2018.02.004 (2018).
    https://www.ncbi.nlm.nih.gov/pubmed/29533781
  • Shukunami, C., A. Takimoto, Y. Y. Nishizaki, Y. Yoshimoto, S. Tanaka, S. Miura, H. Watanabe, T. Sakuma, T. Yamamoto, G. Kondoh, Y. Hiraki.
    Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes. Scientific Reports, 8(1):3155. doi: 10.1038/s41598-018-21194-3 (2018).
    https://www.ncbi.nlm.nih.gov/pubmed/29453333
  • Tsubaki, T., T. Kadonosono, S. Sakurai, T. Shiozawa, T. Goto, S. Sakai, T. Kuchimaru, T. Sakamoto, H. Watanabe, G. Kondoh, S. Kizaka-Kondoh.
    Novel Adherent CD11b+ Gr-1+ Tumor-infiltrating Cells Initiate an Immunosuppressive Tumor Microenvironment. Oncotarget, https://doi.org/10.18632/oncotarget.24359 (2018).
    https://www.ncbi.nlm.nih.gov/pubmed/29541408
  • Ohashi, M., Y. Umemura, N. Koike, Y. Tsuchiya, Y. Inada, H. Watanabe, T. Tanaka, Y. Minami, O. Ukimura, T. Miki, T. Tajiri, G. Kondoh, Y. Yamada, K. Yagita.
    Disruption of circadian clockwork in in vivo reprogramming-induced mouse kidney tumors. Genes to Cells, 23(2):60-69. doi: 10.1111/gtc.12552 (2018).
    https://www.ncbi.nlm.nih.gov/pubmed/29271044
  • Hara, H., H. Miyata, N-R. Das, J. Cida, T. Yoshimochi, K. Uchiyama, H. Watanabe, G. Kondoh, T. Yokoyama, S. Sakaguchi.
    Prion protein devoid of the octapeptide repeat region abrogates BSE pathogenesis in mice. J. Virol., 92-1, pii: e01368-17, (2017).
    https://www.ncbi.nlm.nih.gov/pubmed/29046443
  • Fujihira, H., Y. Masahara-Negishi, M. Tamura, C. Huang, Y. Harada, S. Wakana, D. Takakura, N. Kawasaki, N. Taniguchi, G. Kondoh, T. Yamashita, Y. Funakoshi, T. Suzuki.
    Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene. PLoS Genet. https://doi.org/10.1371/journal.pgen.1006696(2017).
    https://www.ncbi.nlm.nih.gov/pubmed/28426790
  • Mochizuki AL, Katanaya A, Hayashi E, Hosokawa M, Moribe E, Motegi A, Ishiai M, Takata M, Kondoh G, Watanabe H, Nakatsuji N, Chuma S.
    PARI regulates stalled replication fork processing to maintain genome stability upon replication stress in mice.Mol Cell Biol. 2017 Sep 11.
    https://www.ncbi.nlm.nih.gov/pubmed/28894029
  • Miralles M, Eixarch H, Tejero M, Costa C, Hirota K, Castaño AR, Puig M, Stockinger G, Montalban X, Bosch A, Espejo C, Chillon M.  Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor. Neurotherapeutics. 2017 Jun 7. https://www.ncbi.nlm.nih.gov/pubmed/28593439
  • Watanabe H, Takeda R, Hirota K, Kondoh G. Lipid raft dynamics linked to sperm competency for fertilization in mice. Genes to Cells. 2017 Apr 20
    https://www.ncbi.nlm.nih.gov/pubmed/28425215
  • Yoshimoto Y, Takimoto A, Watanabe H, Hiraki Y, Kondoh G, Shukunami C. Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system. Scientific Reports. 2017 Mar 22.
    https://www.ncbi.nlm.nih.gov/pubmed/28327634
  • Das NR, Miyata H, Hara H, Uchiyama K, Chida J, Yano M, Watanabe H, Kondoh G, Sakaguchi S. Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice. Arc. Virol. 2017 Mar 2.
    https://www.ncbi.nlm.nih.gov/pubmed/28255815
  • Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S.  Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment. Nat Immunol. 2016 Dec 19.
    https://www.ncbi.nlm.nih.gov/pubmed/27992401
  • Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, Takeda K. Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheumatol. 2016 Jun 22.
    http://www.ncbi.nlm.nih.gov/pubmed/27333153
  • Tsuchiya, Y., Y. Minami, Y. Umemura, H. Watanabe, D. Ono, W. Nakamura, T. Takahashi, S. Honma, G. Kondoh, T. Matsuishi, and K. Yagita. Disruption of MeCP2 attenuates circadian rhythm in CRISPR/Cas9-based Rett syndrome model mouse. Genes to Cells, 2015 Dec;20(12):992-1005.
    http://www.ncbi.nlm.nih.gov/pubmed/26456390
  • Sugita, K., S. Hanakawa, T. Honda, G. Kondoh, Y. Miyachi, K. Kabashima, and T. Nomura. Generation of Helios reporter mice and an evaluation of the suppressive capacity of Helios+ regulatory T cells in vitro. Experimental Dermatology, 24-7, 554-556 (2015).
    http://www.ncbi.nlm.nih.gov/pubmed/25846704
  • Watanabe, H., T. Takeo, H. Tojo, K. Sakoh, T. Berger, N. Nakagata, T. W. Mak, and G. Kondoh. Lipocalin2 binds to membrane phosphatidylethanolamine to induce lipid raft movement in a PKA-dependent manner and modulates sperm maturation. Development, 141, 2157-2164 (2014).
    http://www.ncbi.nlm.nih.gov/pubmed/24803661
  • Kim, C-J, Y. Tambe, K-I. Mukaisho, H. Sugihara, T. Isono, H. Sonoda, T. Shimizu, G. Kondoh, and H. Inoue. Female-specific rectal carcinogenesis in cyclin D1b transgenic mice. Carcinogenesis , 35, 227-236 (2014).
    http://www.ncbi.nlm.nih.gov/pubmed/23975835
  • Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali D, Kappler J, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S. Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease. Science. 2014 Oct 17;346(6207):363-8. doi: 10.1126/science.1259077.
    http://www.ncbi.nlm.nih.gov/pubmed/25324392
  • Di Meglio P, Duarte JH, Ahlfors H, Owens ND, Li Y, Villanova F, Tosi I, Hirota K, Nestle FO, Mrowietz U, Gilchrist MJ, Stockinger B. Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions. Immunity. 2014 Jun 19;40(6):989-1001. doi: 10.1016/j.immuni.2014.04.019.
    http://www.ncbi.nlm.nih.gov/pubmed/24909886
  • Umemura Y, J. Yoshida, M. Wada, Y. Tsuchiya, Y. Minami, H. Watanabe, G. Kondoh, J. Takeda, H. Inokawa, K. Horie, and K. Yagita. An in vitro ES cell-based clock recapitulation assay model identifies CK2α as an endogenous clock regulator. PLoS ONE, 8 (6), e67241 (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/23840637
  • Fujihara, Y., Tokuhiro, K., Muro, Y., Kondoh, G., Araki, Y., Ikawa, M., and Okabe, M. Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse sperm. Proc. Natl. Acad. Sci. USA, 110, 8111-8116 (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/23633567
  • Duarte JH, Di Meglio P, Hirota K, Ahlfors H, Stockinger B. Differential Influences of the Aryl Hydrocarbon Receptor on Th17 Mediated Responses in vitro and in vivo. PLoS One. 8:e79819 (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/24244565
  • Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B. Plasticity of TH17 cells in Peyer’s patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol 4, 372-379. (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/23475182
  • Orihashi, K., H. Tojo, K. Okawa, Y. Tashima, T. Morita, and G. Kondoh. Mammalian carboxylesterase (CES) releases GPI-anchored proteins from the cell surface upon lipid raft fluidization. Biol. Chem., 393, 169-176 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22718632
  • Ishimura, A., K-I. Minehata, M. Terashima, G. Kondoh, T. Hara, and T. Suzuki. Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression. Development, 139, 749-759 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22241836
  • Masago Y., A. Hosoya, K. Kawasaki, S. Kawano, A. Nasu, J. Toguchida, K. Fujita, H. Nakamura, G. Kondoh, and K. Nagata. Molucular chaperone Hsp47 is essential for cartilage and endochondral bone formation. J. Cell Sci., 125(5), 1118-1128 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22492985

2011年以前

  • Kadonosono, T., T. Kuchimaru, S. Yamada, Y. Takahashi, A. Murakami, H. Watanabe, T. Tani, M. Inoue, T. Tsukamoto, T. Toyoda, T. Tanaka, K. Hirota, K. Urano, K. Machida, T. Eto, T. Ogura, H. Tsutsumi, M. Ito, M. Hiraoka, G. Kondoh, and S. Kizaka-Kondoh. Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging. PLoS ONE, 6 (11), e26640 (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/22102864
  • Tanaka, T., M. Hosokawa, V-V. Vagin, M. Reuter, E. Hayashi, A-L. Mochizuki, K. Kitamura, H. Yamanaka, G. Kondoh, K. Okawa, S. Kuramochi-Miyagawa, T. Nakano, R. Sachidanandam, G-J. Hannon, R-S. Pillai, N. Nakatsuji, and S. Chuma: Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatid bodies during spermatogenesis. Proc. Natl. Acad. Sci. USA, 108-26, 10579-10584 (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21670278
  • Watanabe, H., and G. Kondoh: Mouse sperm undergo GPI-anchored protein release associated with lipid raft reorganization and acrosome reaction to acquire fertility. J. Cell Sci., 124-15, 2573-2581 (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21750187
  • Wilhelm, C., Hirota, K., Stieglitz, B., Van Snick, J., Tolaini, M., Lahl, K., Sparwasser, T., Helmby, H., and Stockinger, B. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 12, 1071-1077. (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21983833
  • Hirota, K., Duarte, J.H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D.J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U, Garefalaki A, Potocnik AJ, Stockinger B. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12, 255-263. (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21278737
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  • Kouno, M., G. Kondoh, K. Horie, N. Komazawa, N. Ishii, Y. Takahashi, J. Takeda, and T. Hashimoto: Ahnak/Desmoyokin is dispensable for proliferation, differentiation, and maintenance of integrity in mouse epidermis. J. Invest. Dermatol., 123, 700-707 (2004).
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